Joel Spoelsky has posted an article that I can really relate to. I started working for a technical consultancy of about 100 people where you knew nearly everyone. About 18 months ago the company was bought by a much larger consultancy. Since then, mostly through acquisition, the company has grown to over 1200 people. The business unit I work in now is at least twice the size of the company I started at. The culture has changed massively.
The analogies he uses at http://www.joelonsoftware.com/items/2007/08/28.html are so true! I think I prefer the bed and breakfast.